Abstract: 

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Alzheimer’s Disease (AD) is the most common type of dementia worldwide and can have irreparable consequences for the brain. Cognitive decline and neural damage is a result of the tangles and plaque that comes with AD. AD is a multifactorial disease with many factors that contribute to the age of onset, development, and progression of this disease, but the genetic presence, specifically, is polygenic. APOE is a gene that accounts for a large portion of AD risk, but it is not completely causative of the disease. This review aims to search for relevant genetic variants that contribute to AD risk in order to calculate a polygenic risk score to use for future studies. Beginning with 860 individual studies collected through EMBASE and PubMed, this review screened and assessed eligibility until 26 studies fit the inclusion criteria and were included in this analysis. Though both qualitative and quantitative studies were analyzed, this review focused on extracting common and rare mutations and SNPs in genes that contribute to risk. Results reviewed each gene and the corresponding SNPs identified that showed correlation to AD risk. Taken together, the results included over 66 variants that should be accounted for in future PRS.